Gilles Simon fended off Australian ace Bernard Tomic in a rain affected Centre Court contest 7-6 6-3.
The French no2 seed took the pace off the drives from the confident 20-year-old hot-shot, but made heavy weather of progressing to the semi-final.
The tiebreak was fiercely contested, Simon edged ahead 10-8 and made a formidable start to the second set.
But light rain suspended the tie at 4-1 with Tomic set to serve. The return to court was brief, lasting 10 minutes, with Simon sealing success in their first ever encounter but being pegged back from a 5-1 lead.
Tomic narrowly missed out on earning his first semi-final berth since racing to his inaugural ATP Tour crown at Sydney in January.
John, his father and coach, would have been delighted by the start from the world no64 until he fluffed two set points on Simon’s serve at 5-4.
The French ace faces Italian Andreas Seppi, who has roared into his third successive Eastbourne semi-final and won the 2011 AEGON International as well as finished runner-up last year.